Institut für Analytische Chemie, Universität Leipzig, Leipzig, Germany.
Electrophoresis. 2009 Aug;30(16):2765-72. doi: 10.1002/elps.200900153.
Advances in microfluidic chips for chiral separations from 2003 to early 2009 are discussed. Microchip-based separation techniques promise higher speed, throughput, portability, less sample and reagent consumption, better environmental compatibility, reduced cost and the prospect of system integration. Microchip electrophoresis is the most promising technique for miniaturized enantioseparations and has been performed with a variety of designs and analytes, however, other formats such as microchip electrochromatography are also gaining in popularity. Microchip fabrication, chemistry and detection issues are critically discussed and highlighted. Integration of enantioseparation techniques into multifunctional microchips are currently a rapidly advancing area of research and methods are discussed that may eventually enable enantioseparations to be the part of a holistic chemical microchip.
讨论了 2003 年初至 2009 年初微流控芯片在手性分离方面的进展。基于微芯片的分离技术有望实现更高的速度、通量、便携性、更少的样品和试剂消耗、更好的环境兼容性、降低成本以及系统集成的前景。微芯片电泳是用于小型化对映体分离最有前途的技术，已经使用了各种设计和分析物，但是，其他格式，如微芯片电色谱也越来越受欢迎。本文批判性地讨论和强调了微芯片的制造、化学和检测问题。将对映体分离技术集成到多功能微芯片中是当前研究的一个快速发展领域，并讨论了可能最终使对映体分离成为整体化学微芯片一部分的方法。
