健康受试者内源性洋地黄样利钠物质的尿排泄。钠负荷的影响。
Urinary excretion of endogenous digitalis-like natriuretic substances in healthy subjects. Effect of sodium load.
作者信息
Asbert M, Jiménez W, La Villa G, Clària J, López C, Ginés P, Gaya J, Castro A, Rivera F, Arroyo V
机构信息
Laboratorio de Hormonas y Unidad Hepática, Hospital Clínico y Provincial Universidad de Barcelona, Spain.
出版信息
Rev Esp Fisiol. 1990 Sep;46(3):261-7.
In the current study digoxin-like immunoreactivity (DLIA), Na-K-ATPase inhibition and natriuretic activity of urinary extracts from 10 healthy volunteers following a low and a high-sodium intake, respectively, were measured. Detectable urinary DLIA (46.1 +/- 5.6 ng eq digoxin/day), Na-K-ATPase inhibition (182.9 +/- 22.7 nmol eq oub/day) and natriuretic activity (UNaV: 0.38 +/- 0.11 microEq/min) were observed during the low-sodium diet period in all subjects. High-sodium diet was associated with a significant increase in DLIA (87.9 +/- 9.2 ng eq digoxin/day, p less than 0.001) which parallelled changes in Na-K-ATPase inhibition (359.8 +/- 51.9 nmol eq oub/day, p less than 0.005) and natriuretic activity (UNaV: 1.33 +/- 0.3 microEq/min, p less than 0.025). These results support the contention that DLIA is related to NH.
在本研究中，分别测量了10名健康志愿者在低钠和高钠饮食后尿液提取物中的地高辛样免疫反应性（DLIA）、钠钾ATP酶抑制作用和利钠活性。在所有受试者的低钠饮食期间，均观察到可检测到的尿液DLIA（46.1±5.6纳克当量地高辛/天）、钠钾ATP酶抑制作用（182.9±22.7纳摩尔当量哇巴因/天）和利钠活性（尿钠排泄率：0.38±0.11微当量/分钟）。高钠饮食与DLIA显著增加相关（87.9±9.2纳克当量地高辛/天，p<0.001），这与钠钾ATP酶抑制作用（359.8±51.9纳摩尔当量哇巴因/天，p<0.005）和利钠活性（尿钠排泄率：1.33±0.3微当量/分钟，p<0.025）的变化平行。这些结果支持了DLIA与NH相关的观点。
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