Bajzer Z, Vuk-Pavlović S
Division of Development Oncology Research Foundation, Rochester, MN 55905.
Crit Rev Oncog. 1990;2(1):53-73.
Autocrine regulation is defined as a mechanism of self-control in growth and differentiation; this mode of regulation among histologically homologous cells is mediated humorally. Autocrine mechanisms involve: 1. Autonomously controlled production and secretion of autocrine mediators. 2. Distribution of autocrine mediators among cells. 3. Expression by cells of functional receptors for autocrine mediators. 4. Transduction and intracellular integration of signals mediated by autocrine mediators. 5. Growth response. 6. Maintenance of autonomous control of growth and/or differentiation state in the progeny Biochemical and biological evidence for most of these steps in various transformed cells makes it possible to analyze autocrine control as a multifaceted process. This process depends on tumor cellularity and histoarchitecture, on time and on external influences on secretion of autocrine mediators (e.g., estrogens in estrogen-dependent breast cancer). We review the quantitative aspects of experimental evidence for autocrine control in tumors and examine the phenomenological and some mechanistic concepts in creating integrative, quantitative, and experimentally verifiable mathematical models of autocrine regulation.
自分泌调节被定义为生长和分化中的一种自我控制机制；这种组织学上同源细胞间的调节模式是通过体液介导的。自分泌机制包括：1. 自分泌介质的自主控制产生和分泌。2. 自分泌介质在细胞间的分布。3. 细胞对自分泌介质功能性受体的表达。4. 自分泌介质介导信号的转导和细胞内整合。5. 生长反应。6. 子代中生长和/或分化状态自主控制的维持。各种转化细胞中这些步骤大多的生化和生物学证据使得将自分泌控制分析为一个多方面的过程成为可能。这个过程取决于肿瘤细胞数量和组织结构、时间以及对自分泌介质分泌的外部影响（例如，雌激素依赖型乳腺癌中的雌激素）。我们回顾了肿瘤中自分泌控制实验证据的定量方面，并审视了在创建自分泌调节的综合、定量且可实验验证的数学模型中的现象学和一些机制概念。
