Vignon F, Rochefort H
Pathol Biol (Paris). 1983 Nov;31(9):783-7.
The hormone dependence and the prognosis of human breast cancers are now based on the assays of the oestrogen receptor (RE) and progesterone receptor (PR) in the tumor. However, such prediction is not fully accurate since RE may be non functional in some tumors and the estrogenic regulation in PR is not directly correlated with the effects of estrogens on cell growth. Here, we review other estrogen induced proteins. A special emphasis is made on a 52,000 dalton glycoprotein released into the medium by human breast cancer cells. Studies on the regulation and biological role of this protein should improve our understanding of the mechanisms by which estrogens stimulate the growth and spreading of breast cancers. Such secreted proteins could later provide convenient circulatory markers of hormone dependency.
目前，人类乳腺癌的激素依赖性和预后是基于肿瘤中雌激素受体（RE）和孕激素受体（PR）的检测。然而，这种预测并不完全准确，因为在某些肿瘤中RE可能无功能，并且PR中的雌激素调节与雌激素对细胞生长的影响并不直接相关。在此，我们综述其他雌激素诱导蛋白。特别强调一种由人乳腺癌细胞释放到培养基中的52,000道尔顿糖蛋白。对该蛋白的调节和生物学作用的研究应能增进我们对雌激素刺激乳腺癌生长和扩散机制的理解。这类分泌蛋白日后可能提供方便的激素依赖性循环标志物。
