Serikawa Tadao, Mashimo Tomoji, Takizawa Akiko, Okajima Ryoko, Maedomari Naoki, Kumafuji Kenta, Tagami Fumi, Neoda Yuki, Otsuki Mito, Nakanishi Satoshi, Yamasaki Ken-ichi, Voigt Birger, Kuramoto Takashi
Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University.
Exp Anim. 2009 Jul;58(4):333-41. doi: 10.1538/expanim.58.333.
In order to establish a system to facilitate the systematic collection, preservation, and provision of laboratory rats (Rattus norvegicus) and their derivates, the National BioResource Project-Rat (NBRP-Rat) was launched in July 2002. By the end of 2008, more than 500 rat strains had been collected and preserved as live animals, embryos, or sperm. These rat resources are supplied to biomedical scientists in Japan as well as in other countries. This review article introduces NBRP-Rat and highlights the phenome project, recombinant inbred strains, BAC clone libraries, and the ENU-mutant archive, named the Kyoto University Rat Mutant Archive (KURMA). The future direction of rat resources are also discussed.
为建立一个便于系统收集、保存和提供实验大鼠（褐家鼠）及其衍生物的体系，国家生物资源项目-大鼠（NBRP-大鼠）于2002年7月启动。截至2008年底，已收集并作为活体动物、胚胎或精子保存了500多个大鼠品系。这些大鼠资源供应给日本以及其他国家的生物医学科学家。这篇综述文章介绍了NBRP-大鼠，并重点介绍了表型组计划、重组近交系、BAC克隆文库以及名为京都大学大鼠突变体库（KURMA）的ENU突变体库。还讨论了大鼠资源的未来发展方向。
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