Dwinell M R, Takizawa A, Tutaj M, Malloy L, Schilling R, Endsley A, Demos W M, Smith J R, Wang S J, De Pons J, Kundurthi A, Geurts A M, Kwitek A E
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Mamm Genome. 2025 Mar;36(1):25-37. doi: 10.1007/s00335-024-10102-y. Epub 2025 Feb 5.
Rat models have been a major model for studying complex disease mechanisms, behavioral phenotypes, environmental factors, and for drug development and discovery. Inbred rat strains control for genetic background and allow for repeated, reproducible, cellular and whole animal phenotyping. The Hybrid Rat Diversity Panel (HRDP) was designed to be a powerful panel of inbred rats with genomic, physiological, and behavioral data to serve as a resource for systems genetics. The HRDP consists of 96-98 inbred rat strains aimed to maximize power to detect specific genetic loci associated with complex traits while maximizing the genetic diversity among strains. The panel consists of 32-34 genetically diverse inbred strains and two panels of recombinant inbred panels. To establish the HRDP program, embryo resuscitation and breeding were done to establish colonies for distribution. Whole genome sequencing was performed to achieve 30X coverage. Genomic, phenotype, and strain information is available through the Hybrid Rat Diversity Panel Portal at the Rat Genome Database ( http://rgd.mcw.edu ).
大鼠模型一直是研究复杂疾病机制、行为表型、环境因素以及药物开发与发现的主要模型。近交系大鼠可控制遗传背景，并允许进行重复、可重现的细胞和整体动物表型分析。杂交大鼠多样性面板（HRDP）旨在成为一个强大的近交系大鼠面板，拥有基因组、生理学和行为学数据，作为系统遗传学的资源。HRDP由96 - 98个近交系大鼠品系组成，旨在最大限度地提高检测与复杂性状相关的特定基因座的能力，同时最大限度地增加品系间的遗传多样性。该面板由32 - 34个遗传多样的近交系和两个重组近交系面板组成。为了建立HRDP计划，进行了胚胎复苏和繁殖以建立用于分发的群体。进行了全基因组测序以实现30倍覆盖。基因组、表型和品系信息可通过大鼠基因组数据库的杂交大鼠多样性面板门户（http://rgd.mcw.edu）获取。
