Chapman Katie Z, Dale Verity Q, Dénes Adám, Bennett Gavin, Rothwell Nancy J, Allan Stuart M, McColl Barry W
Faculty of Life Sciences, University of Manchester, Manchester, UK.
J Cereb Blood Flow Metab. 2009 Nov;29(11):1764-8. doi: 10.1038/jcbfm.2009.113. Epub 2009 Aug 5.
Increasing evidence suggests that peripheral inflammatory responses to stroke and other brain injuries have an important role in determining neurological outcome. The mediators of this response and the temporal relationships between peripheral and central inflammatory alterations are poorly understood. In this study, we show that experimental stroke in mice induces a peripheral inflammatory response that peaks 4 h after stroke, and precedes the peak in brain inflammation 24 h after stroke. This peripheral response is dominated by the induction of the chemokine CXCL-1 and the proinflammatory cytokine interleukin-6 and could serve as an accessible target for therapy and as a source of biomarkers predictive of prognosis.
越来越多的证据表明，中风和其他脑损伤引发的外周炎症反应在决定神经功能转归方面起着重要作用。人们对这种反应的介质以及外周和中枢炎症变化之间的时间关系了解甚少。在本研究中，我们发现小鼠实验性中风会引发外周炎症反应，该反应在中风后4小时达到峰值，并在中风后24小时大脑炎症达到峰值之前出现。这种外周反应以趋化因子CXCL-1和促炎细胞因子白细胞介素-6的诱导为主，可作为一个易于治疗的靶点以及预测预后生物标志物的来源。
