Yamanari Masahiro, Lim Yiheng, Makita Shuichi, Yasuno Yoshiaki
Computational Optics Group in the University of Tsukuba, Tsukuba, Ibaraki, Japan.
Opt Express. 2009 Jul 20;17(15):12385-96. doi: 10.1364/oe.17.012385.
Polarization-sensitive optical coherence tomography (PS-OCT) can measure cross-sectional and volumetric images of birefringence in fibrous tissues that provides additional contrast to the intensity images. In this study, we develop polarization-sensitive swept-source OCT (PS-SS-OCT) at 1 microm for deep penetration of the sclera and lamina cribrosa in the posterior part of human eyes. A calibration method for polarization mode dispersion of a circulator, which is employed to conserve the optical power of the interferometer and achieve system sensitivity sufficient for retinal imaging is demonstrated. The A-scan rate, the axial resolution, and the sensitivity of the PS-SS-OCT are 28,000 Hz, 11.0 microm, 94.2 dB, respectively. The posterior part of the eyes of a healthy male subject are measured in vivo. Phase-retardation images show birefringence of deep sclera and lamina cribrosa and enhance the contrast which is not visible in the intensity images. In addition, unlike conventional OCT, our PS-SS-OCT showed polarization-insensitive intensity images, in which an artifact created by the birefringence of sclera has been successfully eliminated.
偏振敏感光学相干断层扫描（PS-OCT）可以测量纤维组织中双折射的横截面和体积图像，这为强度图像提供了额外的对比度。在本研究中，我们开发了波长为1微米的偏振敏感扫频源OCT（PS-SS-OCT），用于深入穿透人眼后部的巩膜和筛板。展示了一种用于环行器偏振模色散的校准方法，该环行器用于保持干涉仪的光功率，并实现足以进行视网膜成像的系统灵敏度。PS-SS-OCT的A扫描速率、轴向分辨率和灵敏度分别为28,000 Hz、11.0微米、94.2 dB。对一名健康男性受试者的眼后部进行了活体测量。相位延迟图像显示了深层巩膜和筛板的双折射，并增强了强度图像中不可见的对比度。此外，与传统OCT不同，我们的PS-SS-OCT显示出对偏振不敏感的强度图像，其中由巩膜双折射产生的伪像已被成功消除。
