Eid S R, Cortright D N
Department of Pain Research, Neuroscience Drug Discovery, Merck Research Laboratories, West Point, Philadelphia, USA.
Handb Exp Pharmacol. 2009(194):261-81. doi: 10.1007/978-3-540-79090-7_8.
The somatosensory effects of natural products such as capsaicin, mustard oil, and menthol have been long recognized. Over the last decade, the identification of transient receptor potential (TRP) channels in primary sensory neurons as the targets for these agents has led to an explosion of research into the roles of "thermoTRPs" TRPV1, TRPV2, TRPV3, TRPV4, TRPA1, and TRPM8 in nociception. In concert, through the efforts of many industrial and academic teams, a number of agonists and antagonists of these channels have been discovered, paving the way for a better understanding of sensory biology and, potentially, for novel treatments for diseases.
辣椒素、芥子油和薄荷醇等天然产物的体感效应早已为人所知。在过去十年中，初级感觉神经元中的瞬时受体电位（TRP）通道被确定为这些物质的靶点，这引发了对“热TRP” TRPV1、TRPV2、TRPV3、TRPV4、TRPA1和TRPM8在伤害感受中作用的大量研究。与此同时，通过许多工业和学术团队的努力，已经发现了这些通道的一些激动剂和拮抗剂，为更好地理解感觉生物学以及潜在地为疾病的新治疗方法铺平了道路。
