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温度可控温针针刺对大鼠制动应激性高血压的缓解作用及其外周神经机制

Attenuation of immobilization stress-induced hypertension by temperature-controllable warm needle acupuncture in rats and the peripheral neural mechanisms.

作者信息

Bang Se Kyun, Chang Suchan, Seo Su Yeon, Kang Suk-Yun, Cho Seong Jin, Choi Kwang-Ho, Juping Xing, Kim Hee Young, Ryu Yeonhee

机构信息

Department of Korean Medicine Science Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.

Department of Korean convergence Medical Science, University of Science and Technology, Daejeon, Republic of Korea.

出版信息

Front Neurol. 2023 Jun 13;14:1168012. doi: 10.3389/fneur.2023.1168012. eCollection 2023.

DOI:10.3389/fneur.2023.1168012
PMID:37384285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10294230/
Abstract

INTRODUCTION

We and others have shown that electrical stimulation of the PC-6 acupoint over the wrist relieves hypertension by stimulating afferent sensory nerve fibers and activating the central endogenous opioid system. Warm needle acupuncture has long been utilized to treat various diseases in clinics.

METHODS

Here, we developed a temperature-controllable warm needle acupuncture instrument (WAI) and investigated the peripheral mechanism underlying the effect of warm needle acupuncture at PC-6 on hypertension in a rat model of immobilization stress-induced hypertension.

RESULTS

Stimulation with our newly developed WAI and traditional warm needle acupuncture attenuated hypertension development. Such effects were reproduced by capsaicin (a TRPV1 agonist) injection into PC-6 or WAI stimulation at 48°C. In contrast, PC-6 pretreatment with the TRPV1 antagonist capsazepine blocked the antihypertensive effect of WAI stimulation at PC-6. WAI stimulation at PC-6 increased the number of dorsal root ganglia double-stained with TRPV1 and CGRP. QX-314 and capsaicin perineural injection into the median nerve for chemical ablation of small afferent nerve fibers (C-fibers) prevented the antihypertensive effect of WAI stimulation at PC-6. Additionally, PC-6 pretreatment with RTX ablated the antihypertensive effect of WAI stimulation.

CONCLUSION

These findings suggest that warm needle acupuncture at PC-6 activates C-fiber of median nerve and the peripheral TRPV1 receptors to attenuate the development of immobilization stress-induced hypertension in rats.

摘要

引言

我们和其他人已经表明，对腕部的内关穴进行电刺激可通过刺激传入感觉神经纤维并激活中枢内源性阿片系统来缓解高血压。温针疗法长期以来一直在临床上用于治疗各种疾病。

方法

在此，我们开发了一种温度可控的温针仪器（WAI），并研究了在固定应激诱导的高血压大鼠模型中，内关穴温针疗法对高血压影响的外周机制。

结果

用我们新开发的WAI和传统温针疗法进行刺激可减轻高血压的发展。通过向内关穴注射辣椒素（一种TRPV1激动剂）或在48°C下进行WAI刺激可重现这种效果。相比之下，用TRPV1拮抗剂辣椒平对内关穴进行预处理可阻断WAI刺激内关穴的降压作用。在PC-6处进行WAI刺激增加了背根神经节中TRPV1和CGRP双染的数量。向正中神经周围注射QX-314和辣椒素以化学消融小的传入神经纤维（C纤维）可阻止WAI刺激PC-6的降压作用。此外，用RTX对内关穴进行预处理可消除WAI刺激的降压作用。

结论

这些发现表明，内关穴温针疗法可激活正中神经的C纤维和外周TRPV1受体，以减轻大鼠固定应激诱导的高血压的发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/10294230/a05c9c2bc13d/fneur-14-1168012-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/10294230/1e1054ae3c7f/fneur-14-1168012-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/10294230/f8d246fa628a/fneur-14-1168012-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/10294230/b2c3f4bfc6f5/fneur-14-1168012-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/10294230/2a712ca6c3ae/fneur-14-1168012-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/10294230/34bee5bb1e94/fneur-14-1168012-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/10294230/a05c9c2bc13d/fneur-14-1168012-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/10294230/1e1054ae3c7f/fneur-14-1168012-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/10294230/f8d246fa628a/fneur-14-1168012-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/10294230/b2c3f4bfc6f5/fneur-14-1168012-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/10294230/2a712ca6c3ae/fneur-14-1168012-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/10294230/34bee5bb1e94/fneur-14-1168012-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/10294230/a05c9c2bc13d/fneur-14-1168012-g006.jpg

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