Remacle M, Marbaix E, Mustin V
Service ORL et Chirurgie Cervico-faciale, Cliniques de l'Université de Louvain, Belgique.
Acta Otorhinolaryngol Belg. 1990;44(4):423-7.
A new implant made of purified fibrillar collagen (P.F.C.) and hydroxylapatite particles (HA) (Maxill-HAPR) is tested in canine mandibulae and surrounding tissues so that its integration and its bone-induction capacity can be histologically studied. A clinical case is also reported. The goal of this combined implant is to improve the interface of the HA particles with the host-tissues through the P.F.C. This study shows that P.F.C. is replaced after two months by host fibro-conjunctive tissues. Between 3 and 4 months, ossification areas are observed. After 6 months, the host conjunctive tissue is replaced by bone surrounding the HA particles. P.F.C.-HA implants can be made for replacement or restoration of facial bones not submitted to important forces like the frontal or malar bones.
一种由纯化的纤维状胶原蛋白（P.F.C.）和羟基磷灰石颗粒（HA）（Maxill - HAPR）制成的新型植入物在犬类下颌骨及周围组织中进行测试，以便从组织学角度研究其整合情况和骨诱导能力。同时还报告了一个临床病例。这种组合式植入物的目标是通过P.F.C.改善HA颗粒与宿主组织的界面。本研究表明，两个月后P.F.C.被宿主纤维结缔组织取代。在3至4个月之间，观察到骨化区域。6个月后，宿主结缔组织被HA颗粒周围的骨组织取代。P.F.C.-HA植入物可用于替代或修复未承受如额骨或颧骨等重要力量的面部骨骼。
