Liebmann C, Reissmann S
Department of Biology, Friedrich Schiller University, Jena.
Biomed Biochim Acta. 1990;49(11):1231-4.
Bradykinin (BK) which contracts the rat uterus inhibited at subnanomolar concentrations rat myometrial adenylate cyclase stimulated by NaF or guanyl nucleotides by about 40%. The effect was maximal at about 10 to 100 pM. At a higher concentration (100 nM), bradykinin was ineffective. Together with recently presented results these data suggest that in rat myometrium the adenylate cyclase may be coupled by a G12/G13-type G-protein to a high-affinity BK receptor.
使大鼠子宫收缩的缓激肽（BK）在亚纳摩尔浓度时，可抑制由氟化钠或鸟苷酸刺激的大鼠子宫肌层腺苷酸环化酶，抑制率约为40%。该效应在约10至100皮摩尔时达到最大。在较高浓度（100纳摩尔）时，缓激肽无效。结合最近公布的结果，这些数据表明，在大鼠子宫肌层中，腺苷酸环化酶可能通过G12/G13型G蛋白与高亲和力的BK受体偶联。
