Liebmann C, Reissmann S
Department of Biology, Friedrich Schiller-University Jena, GDR.
Biomed Biochim Acta. 1988;47(6):471-4.
A modified bradykinin partial sequence (PP) contracts the isolated rat duodenum, inhibits the adenylate cyclase activity and decreases the cAMP level. These effects are dependent on the presence of free Ca++. The PP acts in contrast to bradykinin itself, which relaxes the rat duodenum and stimulates adenylate cyclase. The results further support the involvement of both cAMP and Ca++ in bradykinin action on rat duodenum smooth muscle.
一种修饰的缓激肽部分序列（PP）可使离体大鼠十二指肠收缩，抑制腺苷酸环化酶活性并降低cAMP水平。这些效应依赖于游离Ca++的存在。与缓激肽本身相反，PP起作用，缓激肽可使大鼠十二指肠松弛并刺激腺苷酸环化酶。结果进一步支持了cAMP和Ca++均参与缓激肽对大鼠十二指肠平滑肌的作用。
