Syrjänen K, Yliskoski M, Kataja V, Hippeläinen M, Syrjänen S, Saarikoski S, Ryhänen A
Department of Pathology, University of Kuopio, Finland.
Int J STD AIDS. 1990 Nov;1(6):410-5. doi: 10.1177/095646249000100604.
The results of the nationwide, population-based cervical cancer screening programme (organized by the Finnish Cancer Society since early 1960s) were analysed to establish the prevalence figures (and their changes) for genital human papillomavirus (HPV) infections in an unselected Finnish female population (aged between 20 and 65 years) screened in Kuopio Province between 1981 and 1989. During the study period 82,393 women were invited on a regular basis for the mass-screening, and also 4131 women in a risk group. Of these, a total of 63,115 and 3249 women attended, resulting in the attendance rates of 76.6% and 78.6%, respectively. As a result of the screening, a total of 509 (0.80%) of the 63,115 smears were diagnosed as having the cytological changes consistent with HPV infection in the mass screening. The corresponding figures in the risk group screening were 58/3249 (1.78%). There was a sharply increasing trend in the prevalence of genital HPV infections from 1981 through 1987, from 0.04% to 1.76% (ie a 44-fold increase in 7 years) which, surprisingly, then declined to 1.43% in 1988 and 1.04% in 1989. Based on a random sample of 2084 routine (non-mass-screening) Pap smears (out of (28,861) collected from the files of our laboratory, the prevalence of HPV infections was stratified by age groups. The highest prevalence (6.1%) was observed in women aged between 20 and 29 years, followed by 2.2% in those aged 30-39 years. Using the figures of the relative risk (RR) of HPV infections by age, an estimation was made to assess the prevalence of clinical HPV infections in the Finnish female population in general.(ABSTRACT TRUNCATED AT 250 WORDS)
对全国性、基于人群的宫颈癌筛查项目（自20世纪60年代初由芬兰癌症协会组织）的结果进行了分析，以确定1981年至1989年在库奥皮奥省接受筛查的未经过挑选的芬兰女性人群（年龄在20至65岁之间）中生殖器人乳头瘤病毒（HPV）感染的患病率数据（及其变化情况）。在研究期间，82393名女性被定期邀请参加大规模筛查，还有4131名处于风险组的女性。其中，分别有63115名和3249名女性参加，参与率分别为76.6%和78.6%。筛查结果显示，在大规模筛查的63115份涂片样本中，共有509份（0.80%）被诊断为具有与HPV感染相符的细胞学变化。在风险组筛查中的相应数据为58/3249（1.78%）。1981年至1987年，生殖器HPV感染的患病率呈急剧上升趋势，从0.04%升至1.76%（即7年增长了44倍），令人惊讶的是，随后在1988年降至1.43%，1989年降至1.04%。基于从我们实验室档案中收集的28861份常规（非大规模筛查）巴氏涂片样本中的2084份随机样本，按年龄组对HPV感染的患病率进行了分层。20至29岁女性的患病率最高（6.1%），其次是30至39岁女性，患病率为2.2%。利用各年龄组HPV感染的相对风险（RR）数据，对芬兰女性总体人群中临床HPV感染的患病率进行了评估。（摘要截选至250词）
