Syrjänen K, Hakama M, Saarikoski S, Väyrynen M, Yliskoski M, Syrjänen S, Kataja V, Castrén O
Department of Pathology, University of Kuopio, Finland.
Sex Transm Dis. 1990 Jan-Mar;17(1):15-9.
The authors derived prevalence and incidence figures for cervical human papillomavirus (HPV) infections in an unselected Finnish population of women aged 22. This paper is an epidemiologic study utilizing the mass-screening program that has been conducted in Finland for cervical cancer since the early 1960s. The authors estimated the lifetime risk of cervical HPV infections based on the figures in this program and on those derived from a random sample of 2,084 (out of 28,861) routine Papanicolaou (Pap) smears examined in their laboratory. The mass-screening program was performed between 1985-1986 focusing on a total cohort of 22-year-old women (born in 1963) in Kuopio province. In 1985, 2,013 women were invited of which 1,289 attended. One year later, 1,768 women of those 2,013 were reinvited, and the number of women screened at the second round was 1,069. The routine cervicovaginal Pap smears were taken, including a cell sample from the vagina, exocervix, and endocervix. All smears were screened for the HPV-induced cytopathic changes by the same cytopathologist. The prevalence of HPV infection among the 22-year-old women was about 3% at the beginning of the follow-up and about 7% one year later. The crude annual incidence was 7.0%. According to the estimates for the life-time risk, half of the sexually active women would experience at least one HPV infection within 10 years. Up to 79% of the Finnish females would contract at least one HPV infection between ages 20 and 79 years. This indicates that factors, which are poorly understood at the moment, exist that regulate the development of an invasive carcinoma from a CIS lesion.
作者得出了芬兰22岁未经过挑选的女性人群中宫颈人乳头瘤病毒（HPV）感染的患病率和发病率数据。本文是一项流行病学研究，利用了自20世纪60年代初以来芬兰开展的宫颈癌大规模筛查项目。作者根据该项目的数据以及从其实验室检查的28861份常规巴氏涂片（Pap涂片）中随机抽取的2084份样本得出的数据，估算了宫颈HPV感染的终身风险。大规模筛查项目于1985 - 1986年进行，重点关注库奥皮奥省出生于1963年的22岁女性这一整个队列。1985年，邀请了2013名女性，其中1289名参加。一年后，再次邀请了这2013名女性中的1768名，第二轮筛查的女性人数为1069名。采集了常规宫颈阴道Pap涂片，包括来自阴道、宫颈外口和宫颈管内口的细胞样本。所有涂片均由同一位细胞病理学家筛查HPV引起的细胞病变。在随访开始时，22岁女性中HPV感染的患病率约为3%，一年后约为7%。粗年发病率为7.0%。根据终身风险估计，一半的性活跃女性在10年内至少会经历一次HPV感染。高达79%的芬兰女性在20至79岁之间至少会感染一次HPV。这表明存在目前尚不清楚的因素调节着从原位癌病变发展为浸润性癌。
