一种用于组装S-连接类糖肽的高效模块化方法。

An efficient modular approach for the assembly of s-linked glycopeptoids.

作者信息

Comegna Daniela, De Riccardis Francesco

机构信息

Dipartimento di Chimica, Università di Salerno, Via Ponte don Melillo, 84084 Fisciano (SA), Italy.

出版信息

Org Lett. 2009 Sep 3;11(17):3898-901. doi: 10.1021/ol901524k.

DOI:10.1021/ol901524k

PMID:19655735

Abstract

A short and convenient methodology for the synthesis of S-glycosylated peptoid models is described. The thioglycosylated building blocks were prepared from proper peracetylated sugars via glycosyl iodides in a one-pot fashion and directly employed in a submonomer solid-phase stategy.

摘要

本文描述了一种用于合成S-糖基化类肽模型的简短且便捷的方法。硫代糖基化构建模块是由适当的全乙酰化糖通过糖基碘以一锅法制备的，并直接用于亚单体固相策略中。