Service of Laboratory, National Institute for Oncology, Rabat, Morocco.
Fundam Clin Pharmacol. 2009 Oct;23(5):549-56. doi: 10.1111/j.1472-8206.2009.00738.x. Epub 2009 Jul 28.
Many natural components of plants extract are studied for their beneficial effects on health and particularly on carcinogenesis chemoprevention. In this study, we investigated the effect of citral (3,7-dimethyl-2,6-octadienal), a key component of essential oils extracted from several herbal plants, on the proliferation rate, cell cycle distribution, and apoptosis of the human breast cancer cell line MCF-7. The effects of this compound were also tested on cyclo-oxygenase activity. Citral treatment caused inhibition of MCF-7 cell growth (IC(50)-48 h: 18 x 10(-5)m), with a cycle arrest in G(2)/M phase and apoptosis induction. Moreover, we observed a decrease in prostaglandin E(2) synthesis 48 h after citral treatment. These findings suggest that citral has a potential chemopreventive effect.
许多植物提取物的天然成分因其对健康的有益作用而受到研究，尤其是对癌症发生的化学预防作用。在这项研究中，我们研究了柠檬醛（3,7-二甲基-2,6-辛二烯醛）对人乳腺癌 MCF-7 细胞系增殖率、细胞周期分布和细胞凋亡的影响。这种化合物的作用也在环氧化酶活性方面进行了测试。柠檬醛处理导致 MCF-7 细胞生长受到抑制（IC（50）-48 h：18 x 10（-5）m），细胞周期停滞在 G2/M 期并诱导细胞凋亡。此外，我们观察到柠檬醛处理后 48 小时前列腺素 E2 的合成减少。这些发现表明柠檬醛具有潜在的化学预防作用。
