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N-(二苯甲基)-D,L-色氨酸甲酯:合成及苯二氮䓬受体亲和力

Methyl N-(diphenylmethyl)-D,L-tryptophanates: synthesis and benzodiazepine receptor affinity.

作者信息

Balsamini C, Duranti E, Salvatori A, Spadoni G, Barone D

机构信息

Istituto di Chimica Farmaceutica, Università di Urbino, Italy.

出版信息

Farmaco. 1990 Oct;45(10):1111-7.

PMID:1965622
Abstract

Several Methyl N-(diphenylmethyl)-D,L-tryptophanates were synthetized and the affinity for the central benzodiazepine receptor was measured. Disappointingly, none of the tested compounds showed to be active, even at the high concentration examined.

摘要

合成了几种N-(二苯甲基)-D,L-色氨酸甲酯,并测定了它们对中枢苯二氮䓬受体的亲和力。令人失望的是,即使在检测的高浓度下,所测试的化合物均未显示出活性。

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