Varga A, Schober K E, Holloman C H, Stromberg P C, Lakritz J, Rings D M
Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, OH, USA.
J Vet Intern Med. 2009 Sep-Oct;23(5):1108-16. doi: 10.1111/j.1939-1676.2009.0355.x. Epub 2009 Jul 28.
Cardiac troponin I (cTnI) is used as a biomarker of myocardial injury in people and small animals. Little is known about the diagnostic use of cTnI in cattle.
Serum cTnI correlates to myocardial function and histopathologic lesions in cattle with monensin-induced myocardial injury.
Ten healthy cows.
Experimental study. Animals received 1 dose of monensin PO; 30 mg/kg (n = 1) or 40 mg/kg (n = 1) (Group A) or 50 mg/kg monensin (n = 8) (Group B) of body weight. Repeated measurements were performed of serum cTnI, biochemistry, and ECG and echocardiography until study termination at 80 (Group A) and 144 hours (Group B) after dosing. Semiquantitative histopathologic examinations of the heart were performed in each cow. A scoring system with regard to the magnitude of myocardial injury was established and a total heart score was compared with maximum cTnI concentration measured after monensin administration. Five hearts from healthy cows served as controls.
Increased cTnI (>0.07 ng/mL) was found in 9/10 cows. cTnI was significantly associated with left ventricular shortening fraction (r(2)= 0.51; P= .02) and myocardial histopathologic lesion score (r(2)= 0.49; P= .021). All cows (n = 7) with evidence of myocardial necrosis had a cTnI concentration > or = 1.04 ng/mL.
cTnI is related to myocardial necrosis and severity of myocardial damage in cattle with monensin toxicosis. cTnI could become a useful diagnostic tool in the noninvasive assessment of myocardial injury in cattle with naturally occurring cardiac disease.
心肌肌钙蛋白I（cTnI）被用作人和小动物心肌损伤的生物标志物。关于cTnI在牛中的诊断用途知之甚少。
血清cTnI与莫能菌素诱导的心肌损伤牛的心肌功能和组织病理学病变相关。
10头健康奶牛。
实验研究。动物口服1剂莫能菌素；按体重计30 mg/kg（n = 1）或40 mg/kg（n = 1）（A组）或50 mg/kg莫能菌素（n = 8）（B组）。在给药后80小时（A组）和144小时（B组）直至研究结束，对血清cTnI、生化指标、心电图和超声心动图进行重复测量。对每头奶牛的心脏进行半定量组织病理学检查。建立了关于心肌损伤程度的评分系统，并将总心脏评分与莫能菌素给药后测得的最大cTnI浓度进行比较。来自健康奶牛的5个心脏用作对照。
10头奶牛中有9头cTnI升高（>0.07 ng/mL）。cTnI与左心室缩短分数显著相关（r² = 0.51；P = 0.02）和心肌组织病理学病变评分显著相关（r² = 0.49；P = 0.021）。所有有心肌坏死证据的奶牛（n = 7）cTnI浓度≥1.04 ng/mL。
cTnI与莫能菌素中毒牛的心肌坏死和心肌损伤严重程度相关。cTnI可能成为自然发生心脏病的牛心肌损伤无创评估的有用诊断工具。
