Carney H C, England J J, Hodgin E C, Whiteley H E, Adkison D L, Sundberg J P
Feline Medical Clinic, Baton Rouge, LA 70810.
J Vet Diagn Invest. 1990 Oct;2(4):294-9. doi: 10.1177/104063879000200407.
Papillomavirus infection was confirmed in 2 Persian cats with sessile hyperkeratotic skin lesions. Skin lesions were not typical papillomas as found in other species. Papillomavirus were demonstrated in negative stain preparations of homogenized tissue and within nuclei of cells in the stratum granulosum. Papillomavirus group-specific antigens were detected within nuclei corresponding to those containing virions. Attempts to transmit this disease to other cats or propagate the virus in tissue cultures were unsuccessful. A 7.8-kilobase DNA molecule was present in low-stringency Southern blots using a bovine papillomavirus type 1 cloned DNA probe. In reverse Southern blots, the cat papillomavirus hybridized under conditions of low stringency with all papillomavirus genomes tested. Combined with limited restriction endonuclease restriction mapping, the above information indicates that the feline cutaneous papillomavirus is a unique virus type and thus expands the list of hosts known to be infected by papillomaviruses.
在2只患有无柄角质化过度性皮肤病变的波斯猫中确诊了乳头瘤病毒感染。皮肤病变并非其他物种中常见的典型乳头瘤。在匀浆组织的负染制剂以及颗粒层细胞的细胞核内发现了乳头瘤病毒。在与含有病毒粒子的细胞核相对应的细胞核内检测到了乳头瘤病毒属特异性抗原。将这种疾病传染给其他猫或在组织培养中繁殖该病毒的尝试均未成功。使用1型牛乳头瘤病毒克隆DNA探针进行的低严谨度Southern杂交中，存在一个7.8千碱基的DNA分子。在反向Southern杂交中，猫乳头瘤病毒在低严谨度条件下与所有测试的乳头瘤病毒基因组杂交。结合有限的限制性内切酶限制图谱分析，上述信息表明猫皮肤乳头瘤病毒是一种独特的病毒类型，从而扩大了已知感染乳头瘤病毒的宿主名单。
