Egberink Herman, Hartmann Katrin, Mueller Ralf, Pennisi Maria Grazia, Belák Sándor, Tasker Séverine, Möstl Karin, Addie Diane D, Boucraut-Baralon Corine, Frymus Tadeusz, Hofmann-Lehmann Regina, Marsilio Fulvio, Thiry Etienne, Truyen Uwe, Hosie Margaret J
Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, University of Utrecht, 3584 CL Utrecht, The Netherlands.
Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, LMU Munich, 80539 Munich, Germany.
Viruses. 2025 Jan 2;17(1):59. doi: 10.3390/v17010059.
Different types of feline papillomaviruses (PVs) are associated with a variety of skin lesions and neoplasia, such as papillomas and cell carcinomas, but the virus can also be found in healthy skin. In this review, the European Advisory Board on Cat Diseases (ABCD), a scientifically independent board of veterinary experts on feline infectious diseases from 11 European Countries, discusses the current knowledge of feline PV infections. Cats most likely become infected through lesions or abrasions of the skin. Most PV infections remain asymptomatic. Besides cat-specific PVs, DNA sequences most closely related to human and bovine PVs have been detected in feline skin lesions. Diagnosis is supported by the histological detection of PV-induced cell changes and intralesional detection of viral antigen (immunostaining) or viral DNA (in situ hybridization). Immunostaining of p16CDKN2A protein (p16) can be performed as a proxy marker for PV-induced neoplasms. There is no specific treatment for PV-induced skin lesions. Spontaneous regression commonly occurs. In the case of invasive squamous cell carcinoma (ISCC), complete excision should be considered, if possible.
不同类型的猫乳头瘤病毒（PVs）与多种皮肤病变和肿瘤形成有关，如乳头状瘤和细胞癌，但在健康皮肤中也能发现该病毒。在本综述中，欧洲猫病咨询委员会（ABCD），一个由来自11个欧洲国家的猫传染性疾病兽医专家组成的科学独立委员会，讨论了目前关于猫PV感染的知识。猫最有可能通过皮肤病变或擦伤而感染。大多数PV感染没有症状。除了猫特异性PVs外，在猫皮肤病变中还检测到了与人类和牛PVs关系最密切的DNA序列。PV诱导的细胞变化的组织学检测以及病变内病毒抗原（免疫染色）或病毒DNA（原位杂交）的检测有助于诊断。p16CDKN2A蛋白（p16）的免疫染色可作为PV诱导肿瘤的替代标志物。对于PV诱导的皮肤病变没有特效治疗方法。通常会自发消退。对于浸润性鳞状细胞癌（ISCC），如果可能的话，应考虑彻底切除。
