患者患有高免疫球蛋白 D 综合征，出现钱币状角膜病变。
Nummular keratopathy in a patient with Hyper-IgD Syndrome.
机构信息
Washington University School of Medicine, 660 South Euclid Ave, Saint Louis, Missouri 63110, USA.
出版信息
Pediatr Rheumatol Online J. 2009 Aug 5;7:14. doi: 10.1186/1546-0096-7-14.
Abstract
PURPOSE
To report a case of recurrent nummular keratitis in a pediatric patient with Hyperimmunoglobulinemia D syndrome.
METHODS
A retrospective chart review.
RESULTS
A 14-year-old boy with Hyperimmunoglobulinemia D syndrome (HIDS) presented with photophobia and ocular irritation concomitant with disease exacerbation. He was found on exam to have significant nummular keratitis, which responded to a short course of topical steroids. Despite acute response to local immunosuppression, the patient had several recurrent attacks and eventually developed a large corneal scar and decreased vision. After initiation of infliximab therapy his ocular sequelae improved dramatically and his vision returned to 20/20.
CONCLUSION
One possible form of end-organ damage associated with HIDS is vision threatening nummular keratopathy.
摘要
目的
报告一例儿童高免疫球蛋白 D 综合征（HIDS）患者反复发作的钱币状角膜炎病例。
方法
回顾性病历分析。
结果
一名 14 岁男孩患有 HIDS（高免疫球蛋白 D 综合征），在疾病加重时出现畏光和眼部刺激。检查发现他有明显的钱币状角膜炎，局部应用皮质类固醇治疗后迅速缓解。尽管局部免疫抑制有急性反应，但患者反复发作数次，最终发展为大的角膜瘢痕和视力下降。开始使用英夫利昔单抗治疗后，他的眼部后遗症明显改善，视力恢复至 20/20。
结论
HIDS 相关的一种可能的靶器官损害形式是威胁视力的钱币状角膜病变。
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