Origlieri Catherine, Bielory Leonard
Division of Allergy, Immunology and Rheumatology, UMDNJ, New Jersey Medical School, Springfield, NJ 07081, USA.
Curr Allergy Asthma Rep. 2009 Jul;9(4):304-10. doi: 10.1007/s11882-009-0043-0.
Allergic rhinoconjunctivitis (ARC) is a commonallergic condition associated with high financial costs and decreased quality of life. Medical treatment options are extensive and include oral, ophthalmic, and intranasal agents. Intranasal corticosteroids (INS) have traditionally been used for chronic management of nasal symptoms, but have also demonstrated an impact on decreasing ocular symptoms of itching, tearing, and redness. Study design, including the method and timing of scoring ocular symptoms, is an important factor affecting whether changes in ocular symptoms are detected in INS clinical trials. INS are thought to exert their influence on the eye through the naso-ocular reflex, and to date their impact on ocular symptoms appears to be a class effect.
变应性鼻结膜炎（ARC）是一种常见的变应性疾病，会产生高昂的经济成本并降低生活质量。医学治疗选择广泛，包括口服、眼科和鼻内用药。鼻内用糖皮质激素（INS）传统上用于慢性鼻症状的管理，但也已证明对减轻眼部瘙痒、流泪和发红等症状有作用。研究设计，包括眼部症状评分的方法和时间，是影响在INS临床试验中是否能检测到眼部症状变化的一个重要因素。INS被认为是通过鼻眼反射对眼睛发挥作用，迄今为止它们对眼部症状的影响似乎是一种类效应。
