Smith Roy G
Department of Metabolism and Aging, The Scripps Research Institute Florida, Jupiter, FL 33458, USA.
Cell Metab. 2009 Aug;10(2):82-3. doi: 10.1016/j.cmet.2009.07.009.
The octanoylated peptide hormone ghrelin regulates episodic growth hormone release and energy balance. Work in genetically modified mice (Kirchner et al., 2009) now shows that in vivo activity of ghrelin O-acyltransferase (GOAT), responsible for ghrelin octanoylation, decreases during fasting but increases after ingesting medium-chain fatty acid triglycerides (MCT).
辛酰化肽激素胃饥饿素调节生长激素的间歇性释放和能量平衡。对基因改造小鼠的研究（Kirchner等人，2009年）表明，负责胃饥饿素辛酰化的胃饥饿素O-酰基转移酶（GOAT）的体内活性在禁食期间降低，但在摄入中链脂肪酸甘油三酯（MCT）后升高。
