人类肠道冠状病毒的进一步研究。
Further studies on human enteric coronaviruses.
作者信息
Caul E O, Egglestone S I
出版信息
Arch Virol. 1977;54(1-2):107-17. doi: 10.1007/BF01314383.
Abstract
Comparisons were made between human enteric coronaviruses and the enteric coronaviruses of pigs and calves by negative staining. Examination of human intestinal organ culture fluids at various time intervals after inoculation with the human enteric coronavirus showed increasing numbers of particles in the fluids. Thin sections of the columnar epithelial cells of these explants showed a number of features consistent with the replication of known human and animal coronaviruses. Virus particles found in thin sections had a mean diameter of 68 nm. In addition, a structure was found in thin sections which has not been described previously. This structure may represent the viral nucleocapsid.
摘要
通过负染色法对人类肠道冠状病毒与猪和牛的肠道冠状病毒进行了比较。在用人类肠道冠状病毒接种后的不同时间间隔对人类肠道器官培养液进行检查，结果显示培养液中的病毒颗粒数量不断增加。这些外植体柱状上皮细胞的超薄切片显示出许多与已知人类和动物冠状病毒复制相符的特征。在超薄切片中发现的病毒颗粒平均直径为68纳米。此外，在超薄切片中还发现了一种以前未描述过的结构。这种结构可能代表病毒核衣壳。
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