Spiegelhalder Kai, Hornyak Magdolna, Kyle Simon David, Paul Dominik, Blechert Jens, Seifritz Erich, Hennig Jürgen, Tebartz van Elst Ludger, Riemann Dieter, Feige Bernd
Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Hauptstrasse 5, 79104 Freiburg, Germany.
Neurocase. 2009 Dec;15(6):527-34. doi: 10.1080/13554790903066909. Epub 2009 Aug 3.
We report the first published case study of a suddenly occurring panic attack in a patient with no prior history of panic disorder during combined functional magnetic resonance imaging (fMRI, 1.5 Tesla) and electrocardiogram (ECG) recording. The single case was a 46-year-old woman who developed a panic attack near the planned end of the fMRI acquisition session, which therefore had to be aborted. Correlational analysis of heart rate fluctuations and fMRI data revealed a significant negative association in the left middle temporal gyrus. Additionally, regions-of-interest (ROI) analyses indicated significant positive associations in the left amygdala, and trends towards significance in the right amygdala and left insula.
我们报告了首例已发表的病例研究，该研究是在一名既往无惊恐障碍病史的患者进行功能磁共振成像（fMRI，1.5特斯拉）和心电图（ECG）同步记录时突然发生惊恐发作的情况。该单一病例为一名46岁女性，在fMRI采集期接近计划结束时出现惊恐发作，因此采集不得不中止。对心率波动和fMRI数据的相关性分析显示，左侧颞中回存在显著的负相关。此外，感兴趣区域（ROI）分析表明，左侧杏仁核存在显著正相关，右侧杏仁核和左侧岛叶有显著性趋势。
