Yarali Nese, Balaban Ismail, Akyurek Nesibe, Ucar Sit, Zorlu Pelin
Dr. Sami Ulus Children's Hospital, Department of Pediatrics, Division of Pediatric Hematology, Ankara, Turkey.
Pediatr Hematol Oncol. 2009 Sep;26(6):461-6. doi: 10.3109/08880010903091897.
Congenital syphilis is a rare, serious disease that continues to be a major health-care problem. The infected neonate may be asymptomatic or multiple-organ system involvement may occur. Anemia and thrombocytopenia are common hematological findings. Hemophagocytic lymphohistiocytosis (HLH) is a clinicopathological condition characterized by activation and uncontrolled nonmalignant proliferation of T lymphocytes and macrophages. The authors report an infant with congenital syphilis as a very rare cause of hemophagocytic syndrome. The reason for anemia and thrombocytopenia in congenital syphilis is not clear. The authors suggest that hemophagocytosis may play role in pathogenesis of cytopenia, particularly thrombocytopenia in patients with congenital syphilis.
先天性梅毒是一种罕见的严重疾病，仍然是一个重大的医疗保健问题。受感染的新生儿可能无症状，也可能出现多器官系统受累。贫血和血小板减少是常见的血液学表现。噬血细胞性淋巴组织细胞增生症（HLH）是一种临床病理状态，其特征是T淋巴细胞和巨噬细胞的激活和不受控制的非恶性增殖。作者报告了一名患有先天性梅毒的婴儿，这是噬血细胞综合征非常罕见的病因。先天性梅毒中贫血和血小板减少的原因尚不清楚。作者认为噬血细胞作用可能在血细胞减少症的发病机制中起作用，尤其是先天性梅毒患者的血小板减少症。
