Duan Baihuan, Zhou Yuefang, Wang Xinyi, Wang Huiqiao, Li Yan, Zhou Xiang, Tang Yujun, Zhu Chenbin, Liu Peng, Peng Jiaofeng
Institute of Pathogenic Biology and Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, Hengyang Medical College, University of South China, Hengyang Central Hospital, Hengyang, China.
Plastic surgery department, the second hospital university of South China, Hengyang, 421001, China.
Infection. 2025 Jun 23. doi: 10.1007/s15010-025-02591-z.
Treponema pallidum (T. pallidum) poses a significant hazard to the health of both expectant mothers and neonates. The bacterium can be transmitted via the placenta from an infected mother to the fetus during pregnancy. Congenital syphilis may occur if the infant is exposed to the infection through contact with the mother's body fluids after delivery. The symptoms of congenital syphilis can severely compromise a newborn's health. In addition to various pathological anomalies, affected children may face skin, bone, internal organ, and nervous system issues. These complications can lead to long-term developmental delays, cognitive impairments, and increased risk of infections. Early detection and treatment are crucial to mitigate these risks and promote healthier outcomes for both the infant and the mother. The worldwide prevalence of congenital syphilis is escalating, rising from 203 cases per 100,000 in 2015 to 295 cases per 100,000 in 2021. The primary treatment for syphilis is currently penicillin G therapy, which produces reliable clinical efficacy. This review offers a thorough analysis of adverse pregnancy outcomes, including preterm birth, miscarriage, stillbirth, and neonatal disorders such as skin lesions and skeletal malformations. The aim is to foster the development of innovative preventive and early diagnostic strategies through a thorough analysis of diagnostic data. These initiatives are expected to reduce the number of affected children significantly, hence enhancing societal stability and safeguarding the health of mothers and infants.
梅毒螺旋体对孕妇和新生儿的健康构成重大危害。这种细菌在怀孕期间可通过胎盘从感染的母亲传播给胎儿。如果婴儿在分娩后通过接触母亲的体液而接触到感染源，可能会发生先天性梅毒。先天性梅毒的症状会严重损害新生儿的健康。除了各种病理异常外，受影响的儿童可能会面临皮肤、骨骼、内脏和神经系统问题。这些并发症可能导致长期发育迟缓、认知障碍以及感染风险增加。早期检测和治疗对于降低这些风险以及促进婴儿和母亲的更健康结局至关重要。先天性梅毒的全球患病率正在上升，从2015年的每10万人203例升至2021年的每10万人295例。梅毒的主要治疗方法目前是青霉素G疗法，其临床疗效可靠。本综述对不良妊娠结局进行了全面分析，包括早产、流产、死产以及皮肤病变和骨骼畸形等新生儿疾病。目的是通过对诊断数据的全面分析，促进创新预防和早期诊断策略的发展。这些举措预计将显著减少受影响儿童的数量，从而增强社会稳定性并保障母婴健康。
