Hui Yonghai, Zhang Qi, Jiang Jun, Lin Lili, Liu Xiaohua, Feng Xiaoming
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, People's Republic of China.
J Org Chem. 2009 Sep 4;74(17):6878-80. doi: 10.1021/jo901425z.
An efficient enantioselective Friedel-Crafts alkylation of indoles to ethyl glyoxylate catalyzed by chiral N,N'-dioxide-Sc(III) complex was developed. The corresponding 3-indolyl(hydroxy)acetates compounds were afforded in good yields with high enantioselectivities (up to 95% ee).
开发了一种由手性N，N'-二氧化物-Sc(III)配合物催化的吲哚与乙醛酸乙酯的高效对映选择性傅克烷基化反应。以良好的收率和高对映选择性（高达95% ee）得到了相应的3-吲哚基（羟基）乙酸酯化合物。
