Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.
Chem Commun (Camb). 2013 Dec 14;49(96):11311-3. doi: 10.1039/c3cc45665j.
An efficient catalytic asymmetric intermolecular C2 Friedel-Crafts alkylation reaction between N-methyl skatole and β,γ-unsaturated α-ketoesters has been realized by a chiral N,N'-dioxide-Ni(II) complex. The corresponding indole derivatives were obtained in good yield (up to 96%) with excellent enantioselectivities (up to 99% ee) under mild reaction conditions.
一种高效的不对称催化的 C2 傅克烷基化反应在 N-甲基 skatole 和β,γ-不饱和α-酮酸酯之间实现了由手性 N，N'-二氧代-Ni（II）配合物。在温和的反应条件下，相应的吲哚衍生物以良好的收率（高达 96%）和优异的对映选择性（高达 99%ee）获得。
