氧化甾醇诱导的液晶相重排：与阿尔茨海默病的可能联系？
Oxysterol-induced rearrangement of the liquid-ordered phase: a possible link to Alzheimer's disease?
作者信息
Mitomo Hideyuki, Chen Wen-Hua, Regen Steven L
机构信息
Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania 18015, USA.
出版信息
J Am Chem Soc. 2009 Sep 2;131(34):12354-7. doi: 10.1021/ja904308y.
Abstract
Nearest-neighbor recognition measurements have been made for an exchangeable phospholipid (A) interacting with an exchangeable form of cholesterol (B) in host membranes derived from 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine and varying concentrations of cholesterol, 7beta-hydroxycholesterol (7beta-OH), and 25-hydroxycholesterol (25-OH). Whereas partial replacement of cholesterol with 7beta-OH strengthens the association between A and B, a similar substitution with 25-OH weakens this association. A model that accounts for this dichotomy, and the possible relevance of these findings to the cytotoxicity of 7beta-OH and to Alzheimer's disease are briefly discussed.
摘要
已经对一种可交换磷脂（A）与可交换形式的胆固醇（B）在由1,2-二棕榈酰-sn-甘油-3-磷酸胆碱和不同浓度的胆固醇、7β-羟基胆固醇（7β-OH）和25-羟基胆固醇（25-OH）衍生的宿主膜中的相互作用进行了近邻识别测量。用7β-OH部分替代胆固醇会增强A和B之间的结合，而用25-OH进行类似替代则会削弱这种结合。简要讨论了一个解释这种二分法的模型，以及这些发现与7β-OH的细胞毒性和阿尔茨海默病的可能相关性。
相似文献
1
Oxysterol-induced rearrangement of the liquid-ordered phase: a possible link to Alzheimer's disease?氧化甾醇诱导的液晶相重排：与阿尔茨海默病的可能联系？
J Am Chem Soc. 2009 Sep 2;131(34):12354-7. doi: 10.1021/ja904308y.
2
Reduced sterol-phospholipid recognition in curved fluid bilayers.弯曲流体双层膜中固醇-磷脂识别能力降低。
Langmuir. 2009 Apr 21;25(8):4328-30. doi: 10.1021/la900346p.
3
A comparative study of the effects of 7β-hydroxycholesterol, 25-hydroxycholesterol, and cholesterol on the structural and thermal phase behavior of multilamellar dipalmitoylphosphatidylcholine bilayer vesicles.7β-羟基胆固醇、25-羟基胆固醇和胆固醇对二棕榈酰磷脂酰胆碱多层囊泡结构和热相变行为影响的比较研究。
Chem Phys Lipids. 2020 Mar;227:104872. doi: 10.1016/j.chemphyslip.2020.104872. Epub 2020 Jan 9.
4
Ethanol-induced reorganization of the liquid-ordered phase: enhancement of cholesterol-phospholipid association.乙醇诱导的液晶相重组：胆固醇-磷脂缔合增强。
J Am Chem Soc. 2006 Jan 11;128(1):265-9. doi: 10.1021/ja056918d.
5
7β-Hydroxycholesterol-induced energy stress leads to sequential opposing signaling responses and to death of C6 glioblastoma cells.7β-羟胆固醇诱导的能量应激导致 C6 神经胶质瘤细胞的连续相反信号反应和死亡。
Biochem Pharmacol. 2012 Jan 1;83(1):37-46. doi: 10.1016/j.bcp.2011.09.022. Epub 2011 Sep 29.
6
Cholesterol-phospholipid association in fluid bilayers: a thermodynamic analysis from nearest-neighbor recognition measurements.流体双层膜中胆固醇与磷脂的缔合：基于最近邻识别测量的热力学分析
Biophys J. 2006 Aug 15;91(4):1402-6. doi: 10.1529/biophysj.106.084152. Epub 2006 Jun 2.
7
Influence of 7α-hydroxycholesterol on sphingomyelin and sphingomyelin/phosphatidylcholine films - The Langmuir monolayer study complemented with theoretical calculations.7α-羟胆固醇对神经鞘磷脂和神经鞘磷脂/磷脂酰胆碱膜的影响——用理论计算补充的 Langmuir 单层研究。
Biochim Biophys Acta Biomembr. 2019 Apr 1;1861(4):861-870. doi: 10.1016/j.bbamem.2019.01.020. Epub 2019 Feb 1.
8
Effects of isoflurane, halothane, and chloroform on the interactions and lateral organization of lipids in the liquid-ordered phase.异氟烷、氟烷和氯仿对液有序相脂质相互作用和侧向组织的影响。
Langmuir. 2011 Dec 6;27(23):14380-5. doi: 10.1021/la2035278. Epub 2011 Oct 28.
9
A chemical sensor for the liquid-ordered phase.一种用于液致有序相的化学传感器。
J Am Chem Soc. 2005 Jun 22;127(24):8813-6. doi: 10.1021/ja0513988.
10
Peptide Recognition of Cholesterol in Fluid Phospholipid Bilayers.胆固醇在液态磷脂双层中的肽识别。
J Am Chem Soc. 2015 Oct 7;137(39):12518-20. doi: 10.1021/jacs.5b08132. Epub 2015 Sep 25.
引用本文的文献
1
Lipids in the Physiopathology of Hereditary Spastic Paraplegias.遗传性痉挛性截瘫生理病理学中的脂质
Front Neurosci. 2020 Feb 28;14:74. doi: 10.3389/fnins.2020.00074. eCollection 2020.
2
Oxysterols Versus Cholesterol in Model Neuronal Membrane. I. The Case of 7-Ketocholesterol. The Langmuir Monolayer Study.模型神经元膜中氧化甾醇与胆固醇的比较。I. 7-酮胆固醇的情况。朗缪尔单分子层研究。
J Membr Biol. 2017 Oct;250(5):553-564. doi: 10.1007/s00232-017-9984-8. Epub 2017 Aug 31.
3
Oxidized cholesterol as the driving force behind the development of Alzheimer's disease.氧化胆固醇是阿尔茨海默病发展背后的驱动力。
Front Aging Neurosci. 2015 Jun 19;7:119. doi: 10.3389/fnagi.2015.00119. eCollection 2015.
4
Sorting of lipidated peptides in fluid bilayers: a molecular-level investigation.脂质化肽在流体双层中的分拣：分子水平的研究。
J Am Chem Soc. 2012 Oct 17;134(41):17245-52. doi: 10.1021/ja3074825. Epub 2012 Oct 4.
5
Effects of isoflurane, halothane, and chloroform on the interactions and lateral organization of lipids in the liquid-ordered phase.异氟烷、氟烷和氯仿对液有序相脂质相互作用和侧向组织的影响。
Langmuir. 2011 Dec 6;27(23):14380-5. doi: 10.1021/la2035278. Epub 2011 Oct 28.
6
The origin of cholesterol's condensing effect.胆固醇缩合作用的起源。
Langmuir. 2011 Mar 15;27(6):2159-61. doi: 10.1021/la105039q. Epub 2011 Feb 14.
7
Phospholipid complexation of general anesthetics in fluid bilayers.普通麻醉剂在流体双层膜中的磷脂复合
Langmuir. 2010 Apr 20;26(8):5309-11. doi: 10.1021/la100712y.
本文引用的文献
1
Perturbations of membrane structure by cholesterol and cholesterol derivatives are determined by sterol orientation.胆固醇及胆固醇衍生物对膜结构的扰动取决于甾醇的取向。
J Am Chem Soc. 2009 Apr 8;131(13):4854-65. doi: 10.1021/ja8095224.
2
Reduced sterol-phospholipid recognition in curved fluid bilayers.弯曲流体双层膜中固醇-磷脂识别能力降低。
Langmuir. 2009 Apr 21;25(8):4328-30. doi: 10.1021/la900346p.
3
The liquid-ordered phase in membranes.膜中的液晶相
Biochim Biophys Acta. 2009 Jan;1788(1):33-46. doi: 10.1016/j.bbamem.2008.08.005. Epub 2008 Aug 15.
4
Thermodynamics of lipid interactions in complex bilayers.复合双层膜中脂质相互作用的热力学
Biochim Biophys Acta. 2009 Jan;1788(1):72-85. doi: 10.1016/j.bbamem.2008.08.007. Epub 2008 Aug 15.
5
Effects of amyloid beta-peptides on the lysis tension of lipid bilayer vesicles containing oxysterols.β-淀粉样肽对含氧化甾醇的脂质双层囊泡裂解张力的影响。
Biophys J. 2008 Jul;95(2):620-8. doi: 10.1529/biophysj.107.114983. Epub 2008 Apr 4.
6
Dynamic molecular structure and phase diagram of DPPC-cholesterol binary mixtures: a 2D-ELDOR study.二棕榈酰磷脂酰胆碱-胆固醇二元混合物的动态分子结构和相图：二维电子电子双共振研究
J Phys Chem B. 2007 Sep 27;111(38):11260-70. doi: 10.1021/jp0732110. Epub 2007 Aug 31.
7
Structures of biologically active oxysterols determine their differential effects on phospholipid membranes.具有生物活性的氧化甾醇的结构决定了它们对磷脂膜的不同作用。
Biochemistry. 2006 Sep 5;45(35):10747-58. doi: 10.1021/bi060540u.
8
Seeing spots: complex phase behavior in simple membranes.看到斑点：简单膜中的复杂相行为。
Biochim Biophys Acta. 2005 Dec 30;1746(3):172-85. doi: 10.1016/j.bbamcr.2005.06.010. Epub 2005 Jul 6.
9
A chemical sensor for the liquid-ordered phase.一种用于液致有序相的化学传感器。
J Am Chem Soc. 2005 Jun 22;127(24):8813-6. doi: 10.1021/ja0513988.
10
Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform.淀粉样β蛋白：Aβ42及其Pro19异构体的单体结构和早期聚集状态
J Am Chem Soc. 2005 Feb 23;127(7):2075-84. doi: 10.1021/ja044531p.
Zotero 插件