普通麻醉剂在流体双层膜中的磷脂复合
Phospholipid complexation of general anesthetics in fluid bilayers.
机构信息
Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania 18015,USA.
出版信息
Langmuir. 2010 Apr 20;26(8):5309-11. doi: 10.1021/la100712y.
Abstract
A nearest-neighbor recognition analysis has been performed in cholesterol-rich and cholesterol-poor liposomes derived from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in the presence of varying concentrations of chloroform. This analysis has yielded a fundamentally new, molecular-level view of the interaction of general anesthetics with lipid bilayers, which may be relevant to their biological action; that is, DPPC forms 1:1 complexes with CHCl(3) in both membranes in the fluid bilayer state.
摘要
在富含胆固醇和贫胆固醇的 1,2-二棕榈酰-sn-甘油-3-磷酸胆碱（DPPC）脂质体中，进行了近邻识别分析，存在不同浓度的氯仿。该分析提供了一般麻醉剂与脂质双层相互作用的全新分子水平视角，这可能与其生物学作用相关；即 DPPC 在双层流体状态下与两种膜中的 CHCl(3) 形成 1:1 配合物。
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3
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