Arnesen Thomas
Department of Molecular Biology, University of Bergen, N-5020 Bergen, Norway.
BMC Proc. 2009 Aug 4;3 Suppl 6(Suppl 6):S1. doi: 10.1186/1753-6561-3-S6-S1.
Protein N-terminal acetylation is a very common modification, but has during the past decades received relatively little attention. In order to put this neglected field back on the scientific map, we have in May 2007 and September 2008 arranged two international NAT symposia in Bergen, Norway. This supplement contains selected proceedings from these symposia reflecting the current status of the field, including an overview of protein N-terminal acetylation in yeast and humans, a novel nomenclature system for the N-terminal acetyltransferases (NATs) and methods for studying protein N-terminal acetylation in vitro and in vivo.
蛋白质N端乙酰化是一种非常常见的修饰,但在过去几十年中受到的关注相对较少。为了使这个被忽视的领域重新回到科学版图上,我们于2007年5月和2008年9月在挪威卑尔根举办了两次国际NAT研讨会。本增刊包含了这些研讨会的部分论文集,反映了该领域的当前状况,包括酵母和人类中蛋白质N端乙酰化的概述、N端乙酰转移酶(NATs)的新命名系统以及体外和体内研究蛋白质N端乙酰化的方法。