Starheim Kristian K, Gromyko Darina, Velde Rolf, Varhaug Jan Erik, Arnesen Thomas
Department of Molecular Biology, University of Bergen, N-5020 Bergen, Norway.
Department of Surgical Sciences, University of Bergen, N-5020 Bergen, Norway.
BMC Proc. 2009 Aug 4;3 Suppl 6(Suppl 6):S3. doi: 10.1186/1753-6561-3-S6-S3.
Protein Nalpha-terminal acetylation is one of the most common protein modifications in eukaryotic cells, occurring on approximately 80% of soluble human proteins. An increasing number of studies links Nalpha-terminal acetylation to cell differentiation, cell cycle, cell survival, and cancer. Thus, Nalpha-terminal acetylation is an essential modification for normal cell function in humans. Still, little is known about the functional role of Nalpha-terminal acetylation. Recently, the three major human N-acetyltransferase complexes, hNatA, hNatB and hNatC, were identified and characterized. We here summarize the identified N-terminal acetyltransferase complexes in humans, and we review the biological studies on Nalpha-terminal acetylation in humans and other higher eukaryotes.
蛋白质Nα-末端乙酰化是真核细胞中最常见的蛋白质修饰之一，大约80%的可溶性人类蛋白质都会发生这种修饰。越来越多的研究将Nα-末端乙酰化与细胞分化、细胞周期、细胞存活和癌症联系起来。因此，Nα-末端乙酰化是人类正常细胞功能的一种重要修饰。然而，人们对Nα-末端乙酰化的功能作用仍知之甚少。最近，已鉴定并表征了三种主要的人类N-乙酰转移酶复合物，即hNatA、hNatB和hNatC。我们在此总结了已鉴定出的人类N-末端乙酰转移酶复合物，并综述了关于人类和其他高等真核生物中Nα-末端乙酰化的生物学研究。
