INSERM, U637, Université Montpellier, France.
J Mol Cell Cardiol. 2010 Jan;48(1):26-36. doi: 10.1016/j.yjmcc.2009.07.026. Epub 2009 Aug 4.
L-type Ca(2+) channels are mediators of Ca(2+) influx and the regulatory events accompanying it and are pivotal in the function and dysfunction of ventricular cardiac myocytes. L-type Ca(2+) channels are located in sarcolemma, including the T-tubules facing the sarcoplasmic reticulum junction, and are activated by membrane depolarization, but intracellular Ca(2+)-dependent inactivation limits Ca(2+) influx during action potential. I(CaL) is important in heart function because it triggers excitation-contraction coupling, modulates action potential shape and is involved in cardiac arrhythmia. L-type Ca(2+) channels are multi-subunit complexes that interact with several molecules involved in their regulations, notably by beta-adrenergic signaling. The present review highlights some of the recent findings on L-type Ca(2+) channel function, regulation, and alteration in acquired pathologies such as cardiac hypertrophy, heart failure and diabetic cardiomyopathy, as well as in inherited arrhythmic cardiac diseases such as Timothy and Brugada syndromes.
L 型钙通道是钙内流及其伴随的调节事件的介质，在心室心肌细胞的功能和功能障碍中起着关键作用。L 型钙通道位于肌膜中，包括面向肌浆网连接的 T 小管，并且通过膜去极化激活，但细胞内 Ca2+依赖性失活限制动作电位期间的 Ca2+内流。I(CaL)在心脏功能中很重要，因为它触发兴奋-收缩偶联，调节动作电位的形状，并参与心律失常。L 型钙通道是多亚基复合物，与涉及它们调节的几个分子相互作用，特别是通过β肾上腺素能信号传导。本综述强调了 L 型钙通道功能、调节以及在获得性病理中的改变的一些最新发现，例如心脏肥大、心力衰竭和糖尿病心肌病，以及遗传性心律失常性心脏病，如 Timothy 和 Brugada 综合征。
