雌二醇可提高小鼠生殖器疱疹疫苗的效力。
Estradiol improves genital herpes vaccine efficacy in mice.
作者信息
Pennock Jeffry W, Stegall Rachael, Bell Brent, Vargas Gracie, Motamedi Massoud, Milligan Gregg, Bourne Nigel
机构信息
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
出版信息
Vaccine. 2009 Sep 25;27(42):5830-6. doi: 10.1016/j.vaccine.2009.07.052. Epub 2009 Aug 4.
Abstract
Herpes Simplex Virus type 2 causes genital herpes but is frequently transmitted asymptomatically; therefore, a prophylactic vaccine is desirable. A candidate vaccine in clinical trials has only shown efficacy in preventing disease in women. Using this subunit vaccine candidate, we were able to demonstrate infection prophylaxis, improved disease prevention and modulated antibody production by complimenting vaccination with estradiol in our murine model. Findings of estradiol-enhanced vaccine efficacy are the first of their kind using a vaccine of this type and have potential clinical relevance to the development of other vaccines and our understanding of gender differences in vaccine efficacy.
摘要
2型单纯疱疹病毒可引起生殖器疱疹，但常无症状传播；因此，预防性疫苗是可取的。一种正在临床试验中的候选疫苗仅在预防女性疾病方面显示出疗效。使用这种候选亚单位疫苗，我们能够在小鼠模型中通过补充雌二醇进行疫苗接种，证明预防感染、改善疾病预防并调节抗体产生。雌二醇增强疫苗效力的研究结果是使用此类疫苗的首例，对其他疫苗的开发以及我们对疫苗效力性别差异的理解具有潜在的临床意义。
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本文引用的文献
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