Bourne Nigel, Stegall Rachael, Montano Raquel, Meador Michael, Stanberry Lawrence R, Milligan Gregg N
Department of Pediatrics, University of Texas Medical Branch, 301 University Blvd., Galveston, Texas, 77555-0436, USA.
Antimicrob Agents Chemother. 2005 Mar;49(3):1181-3. doi: 10.1128/AAC.49.3.1181-1183.2005.
Zinc salt solutions administered as topical microbicides provided significant protection against herpes simplex virus type 2 infection in a mouse vaginal challenge model. However, at the therapeutic concentration, the salt solutions caused sloughing of sheets of vaginal epithelial cells. These observations limit the utility of zinc salts as microbicides and suggest that the application of zinc solutions to mucosal surfaces has the potential to cause damage that might increase susceptibility to secondary infections at a later time.
在小鼠阴道感染模型中，作为局部杀菌剂施用的锌盐溶液对2型单纯疱疹病毒感染提供了显著的保护作用。然而，在治疗浓度下，盐溶液导致阴道上皮细胞成片脱落。这些观察结果限制了锌盐作为杀菌剂的效用，并表明将锌溶液应用于粘膜表面有可能造成损伤，这可能会在以后增加对继发感染的易感性。
