Meerson F Z, Vovk V I
Fiziol Zh SSSR Im I M Sechenova. 1990 Oct;76(10):1298-303.
The adaptation to periodic hypoxia increases the AP duration in the cardiomyocytes of the rat isolated cardiac papillary muscles; prevents the depression of the resting potential, of the AP amplitude and duration in high calcium concentration and high-frequency stimulation. The adaptation also limits the contracture of papillary muscles and the depression of the resting potential in the cardiomyocytes in hypo-sodium solution. The adaptation seems to enhance the efficacy of the membrane mechanisms of the ion transport in cardiomyocytes, whereas subsequent changes in bioelectrical activity play a major part in antiarrhythmic effect of the adaptation.
对周期性缺氧的适应会增加大鼠离体心脏乳头肌心肌细胞的动作电位持续时间；在高钙浓度和高频刺激时可防止静息电位、动作电位幅度和持续时间降低。这种适应还可限制乳头肌的挛缩以及低钠溶液中心肌细胞静息电位的降低。这种适应似乎增强了心肌细胞膜离子转运机制的效能，而生物电活动的后续变化在这种适应的抗心律失常作用中起主要作用。
