Malyshev I Iu, Meerson F Z
Biull Eksp Biol Med. 1990 Mar;109(3):227-9.
It was established in experiment on rat papillary muscle that adaptation to stress exposure increased the myocardial resistance to contractile actions and limited the depression of electrophysiologic parameters induced by the excess of intracellular calcium. This adaptation decreased the contracture in 6.5 times and significantly limited the depression of resting potential (RP) induced by low-sodium (9 mM) perfusing solution. It was shown at the next stage that adaptation limited the depression of electrophysiologic parameters of cardiac cells at high calcium concentrations and high pacing rate. Under these factors the resting potential appeared to be significantly more in adaptation than in control (82 mV vs 69 mV respectively) while the action potential (AP) duration was twofold more. Possible mechanism is discussed of the cardioprotective effect of adaptation to stress exposure associated with the limitation of RP and AP in calcium overload.
在大鼠乳头肌实验中证实，对应激暴露的适应性增强了心肌对收缩作用的抵抗力，并限制了细胞内钙过量引起的电生理参数降低。这种适应性使挛缩降低了6.5倍，并显著限制了低钠（9 mM）灌注液引起的静息电位（RP）降低。在下一阶段表明，适应性限制了高钙浓度和高起搏频率下心细胞电生理参数的降低。在这些因素下，适应性状态下的静息电位明显高于对照组（分别为82 mV和69 mV），而动作电位（AP）持续时间则增加了一倍。讨论了对应激暴露的适应性与钙超载时RP和AP受限相关的心脏保护作用的可能机制。
