一种用于自然杀伤细胞和T细胞大颗粒淋巴细胞白血病侵袭性变体的新型小鼠模型。
A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia.
作者信息
Yokohama Akihiko, Mishra Anjali, Mitsui Takeki, Becknell Brian, Johns Jessica, Curphey Douglas, Blaser Bradley W, Vandeusen Jeffrey B, Mao Hsiaoyin, Yu Jianhua, Caligiuri Michael A
机构信息
Department of Molecular Virology, Immunology, and Medical Genetics, Department of Internal Medicine, Division of Hematology/Oncology, The Ohio State University College of Medicine, Columbus, OH, United States.
出版信息
Leuk Res. 2010 Feb;34(2):203-9. doi: 10.1016/j.leukres.2009.06.031. Epub 2009 Aug 5.
Abstract
Murine models of disease are vital to the understanding of pathogenesis and the development of novel therapeutics. We have previously established interleukin (IL)-15 transgenic (tg) mice that demonstrate rapid proliferation of natural killer (NK) and T cells, followed by spontaneous transformation to lethal leukemia. Herein, we have characterized this model, which has many features in common with the aggressive variants of NK and T large granular lymphocyte leukemia (LGLL) in humans. The LGLL blasts are cytolytic and produce IFN-gammaex vivo. Cytogenetic analysis revealed trisomy of chromosome 17 and/or 15. This model should provide opportunities to develop effective standard therapies for this fatal disease.
摘要
疾病的小鼠模型对于理解发病机制和开发新型治疗方法至关重要。我们之前建立了白细胞介素（IL）-15转基因（tg）小鼠，这些小鼠表现出自然杀伤（NK）细胞和T细胞的快速增殖，随后自发转化为致死性白血病。在此，我们对该模型进行了表征，它具有许多与人类NK和T大颗粒淋巴细胞白血病（LGLL）侵袭性变体相同的特征。LGLL母细胞具有细胞溶解性，并且在体外产生γ干扰素。细胞遗传学分析显示17号和/或15号染色体三体性。该模型应为开发针对这种致命疾病的有效标准疗法提供机会。
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