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白细胞介素-15 在血液系统恶性肿瘤的发生发展和治疗中的作用。

The role of interleukin-15 in the development and treatment of hematological malignancies.

机构信息

Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, United States.

Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, United States.

出版信息

Front Immunol. 2023 Apr 20;14:1141208. doi: 10.3389/fimmu.2023.1141208. eCollection 2023.

DOI:10.3389/fimmu.2023.1141208
PMID:37153603
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10157481/
Abstract

Cytokines are a vital component of the immune system that controls the activation and growth of blood cells. However, chronic overexpression of cytokines can trigger cellular events leading to malignant transformation. The cytokine interleukin-15 (IL-15) is of particular interest, which has been shown to contribute to the development and progression of various hematological malignancies. This review will provide an overview of the impact of the immunopathogenic function of IL-15 by studying its role in cell survival, proliferation, inflammation, and treatment resistance. We will also review therapeutic approaches for inhibiting IL-15 in blood cancers.

摘要

细胞因子是免疫系统的重要组成部分，可控制血细胞的激活和生长。然而，细胞因子的慢性过度表达会引发导致恶性转化的细胞事件。细胞因子白细胞介素-15（IL-15）特别引人注目，它已被证明有助于各种血液恶性肿瘤的发展和进展。通过研究其在细胞存活、增殖、炎症和治疗抵抗中的作用，本综述将概述 IL-15 的免疫发病功能的影响。我们还将回顾抑制血液癌症中 IL-15 的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaa8/10157481/2a2721dd14be/fimmu-14-1141208-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaa8/10157481/2a2721dd14be/fimmu-14-1141208-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aaa8/10157481/2a2721dd14be/fimmu-14-1141208-g001.jpg

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