Virganskiĭ A O, Banin V V, Klevtsov V A, Rogulenko R V, Strupin I V, Tverskaia M S, Tikhvinskaia E I
Fiziol Zh SSSR Im I M Sechenova. 1990 Oct;76(10):1355-60.
In anesthetized dogs with natural breathing, embolisation of pulmonary arterial bed increased systolic pressure in the right ventricle of the heart up to 60.0-113.0 mm Hg. Within 6 hrs the pressure far exceeded initial and control parameters in the minor circulation circle. Tachycardia and tachypnea as well as a reduction of the left ventricle contractions and a decrease of arterial pressure occurred. The massive emboli was followed by an obvious hypoxia and an insignificant hypocapnia with no essential shifts in the blood acid-base balance. Subsequent interstitial oedema of pulmonary tissue may be due both to the changes in the lung hemodynamics and to direct damaging of endothelium in the microvessels.
在自然呼吸的麻醉犬中，肺动脉床栓塞使心脏右心室的收缩压升高至60.0 - 113.0毫米汞柱。6小时内，该压力远远超过小循环圈中的初始参数和对照参数。出现了心动过速、呼吸急促以及左心室收缩减弱和动脉压降低的情况。大量栓子导致明显的低氧血症和轻微的低碳酸血症，血液酸碱平衡无明显变化。随后肺组织的间质性水肿可能是由于肺血流动力学改变以及微血管内皮的直接损伤所致。
