Sprogis W, Mroziński S
Cor Vasa. 1984;26(1):72-8.
Embolisation with allogenic bone marrow administered into the femoral vein was performed in 12 dogs, anaesthetized and heparinized. The ECG and ventricular, aortic and pulmonary artery pressures were recorded by catheterization. From these the following parameters were calculated: cardiac output (CO), by thermodilution; modified cardiac index (CO/M); systolic cardiac index (CO/M/F); work performance of right and left ventricle (Wr, W1); ejection indices of right and left ventricle (Wr/M/F, W1/M/F); first derivative of left ventricular pressure (dp/dt) max and the total pulmonary (TPR) and systemic (TSR) resistance. All parameters were studied also in 12 control ( nonembolized ) dogs. The most significant haemodynamic changes found in the embolized group were as follows: 1) a lowering of the end-diastolic pressure in the left ventricle, of the W1 and W1/M/F, of the Wr with a slight augmentation in the 15th min after embolisation, Wr/M/F and CO/M/F; 2) a rise in heart rate, an augmentation of TPR during the first minutes of the experiment, and of TSR at the end of the experiment.
对12只麻醉并肝素化的犬经股静脉注入同种异体骨髓进行栓塞。通过导管插入术记录心电图以及心室、主动脉和肺动脉压力。据此计算出以下参数：心输出量（CO），采用热稀释法；修正心脏指数（CO/M）；收缩期心脏指数（CO/M/F）；左右心室做功（Wr、W1）；左右心室射血指数（Wr/M/F、W1/M/F）；左心室压力的一阶导数（dp/dt）最大值以及总肺（TPR）和体循环（TSR）阻力。还对12只对照（未栓塞）犬的所有参数进行了研究。栓塞组发现的最显著血流动力学变化如下：1）左心室舒张末期压力降低，W1和W1/M/F降低，Wr降低，栓塞后第15分钟略有升高，Wr/M/F和CO/M/F升高；2）心率升高，实验开始后几分钟TPR升高，实验结束时TSR升高。
