Lesser T, Ebner E, Riedel E, Zwiener U, Runkewitz V
Z Exp Chir Transplant Kunstliche Organe. 1989;22(6):351-9.
Pulmonary embolisms of different clinical degree of severity can be produced by means of the pulmonary embolism model according to Sedlarik by application of electrically activated blood as a thrombogenic substance. An unambiguous influence of the size and the consistency of the thrombus exists concerning the severity of the hemodynamic changes. However, the hemodynamics seems to adapt to the changed conditions of the circulation, because a tendency to normalization was observed in short-term experiments. The morphologic changes after embolisation are more typical for the severity of the clinical picture in this acute phase than the hemodynamics. A testing of the animal model in long-term experiments seem to be ingenious for that reason.
根据塞德拉里克的方法，通过应用电激活血液作为血栓形成物质，利用肺栓塞模型可产生不同临床严重程度的肺栓塞。血栓的大小和稠度对血流动力学变化的严重程度存在明确影响。然而，血流动力学似乎会适应循环条件的改变，因为在短期实验中观察到有恢复正常的趋势。在这个急性期，栓塞后的形态学变化比血流动力学变化更能典型地反映临床症状的严重程度。因此，在长期实验中对动物模型进行测试似乎是明智的。
