Bhatt Lubna, Fernando Indrajit
Department of Oncology, University Hospital Birmingham, B15 2TH, UK.
Clin Breast Cancer. 2009 Aug;9(3):187-8. doi: 10.3816/CBC.2009.n.031.
Pure primary squamous cell carcinoma (SCC) of the breast is rare and difficult to treat. Published series suggest a poor response to conventional breast chemotherapy. A 66-year-old woman with locally advanced SCC of the breast received combined-modality treatment with high-dose radiation therapy (59 Gy in 22 fractions); mastectomy; and chemotherapy with cisplatin 50 mg/m(2), mitomycin-C 6 mg/m(2), and ifosfamide 3 g/m(2) given in 21-day cycles. She remained disease free for 10 years from presentation and died from an unrelated cause. We would suggest that this case lends support to the use of high-dose radiation therapy and platinum-based chemotherapy in the management of this difficult condition.
乳腺原发性纯鳞状细胞癌（SCC）罕见且难以治疗。已发表的系列研究表明，其对传统乳腺癌化疗反应不佳。一名66岁患有局部晚期乳腺SCC的女性接受了综合治疗，包括高剂量放射治疗（22次分割，共59 Gy）、乳房切除术以及顺铂50 mg/m²、丝裂霉素-C 6 mg/m²和异环磷酰胺3 g/m²的化疗，每21天为一个周期。自确诊后她无病生存了10年，最终死于 unrelated cause。我们认为该病例支持在这种棘手病症的治疗中使用高剂量放射治疗和铂类化疗。
