Hiramatsu Kiyoshi, Kato Kenji, Hirata Akihiro, Matsuba Hideki, Hara Tomohiro, Ito Takaaki, Miyata Taishi, Akagawa Takashi, Kutsuna Yasushi, Machiki Yuichi, Fujioka Susumu
Dept. of Surgery, Kiryu Kosei General Hospital.
Gan To Kagaku Ryoho. 2007 Mar;34(3):443-6.
A resected case of squamous cell carcinoma associated with ductal carcinoma in the hemilateral breast successfully treated by FU plus cisplatin (CDDP) adjuvant therapy against recurrent metastases is reported with some discussion. A 42-year-old woman was admitted to our hospital because of right breast tumor. By physical examination, mammography, ultrasound examination and aspirated cytology, we diagnosed squamous cell carcinoma of the right breast. Before operation SCC antigen was elevated. Standard mastectomy was performed, and SCC antigen was decreased within normal range. Then, a standard regimen of chemotherapy using docetaxel with anti-hormonal therapy by LH-RH analog and tamoxifen was done as first-line adjuvant therapy. Four months after operation the SCC antigen level was elevated again, and recurrence of cancer (skin and liver metastases) was recognized. Next, we tried 5-FU/UFT plus CDDP for squamous cell carcinoma of other organs such as the esophagus. These anti-tumor drugs proved effective, and no metastasis of the skin was detected thereafter, and liver metastatic lesion was decreased in ten months. The SCC antigen level was within the normal range again. Additionally, when metastases redeveloped, TS-1 plus CDDP controlled growth of tumors in seven months. Based on the present findings,we recommend adjuvant chemotherapy by FU plus CDDP for squamous cell carcinoma of the breast.
报告了1例患侧乳腺鳞状细胞癌合并导管癌的切除病例，该病例通过氟尿嘧啶和顺铂（CDDP）辅助治疗成功应对复发性转移，并进行了一些讨论。一名42岁女性因右乳肿瘤入住我院。通过体格检查、乳房X线摄影、超声检查和抽吸细胞学检查，我们诊断为右乳鳞状细胞癌。术前鳞状细胞癌抗原（SCC抗原）升高。进行了标准乳房切除术，SCC抗原降至正常范围。然后，采用多西他赛标准化疗方案联合促性腺激素释放激素（LH-RH）类似物和他莫昔芬进行抗激素治疗作为一线辅助治疗。术后4个月，SCC抗原水平再次升高，确诊癌症复发（皮肤和肝转移）。接下来，我们尝试使用5-氟尿嘧啶/优福定联合顺铂治疗其他器官如食管的鳞状细胞癌。这些抗肿瘤药物证明有效，此后未检测到皮肤转移，肝转移灶在10个月内缩小。SCC抗原水平再次恢复正常范围。此外，当转移灶再次出现时，替吉奥联合顺铂在7个月内控制了肿瘤生长。基于目前的研究结果，我们推荐氟尿嘧啶联合顺铂用于乳腺鳞状细胞癌的辅助化疗。
