Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Obesity (Silver Spring). 2010 Feb;18(2):274-81. doi: 10.1038/oby.2009.229. Epub 2009 Aug 6.
The purpose of this study was to determine independent relationships of intra-abdominal adipose tissue (IAAT), leg fat, and aerobic fitness with blood lipids and insulin sensitivity (S(i)) in European-American (EA) and African-American (AA) premenopausal women. Ninety-three EA and ninety-four AA with BMI between 27 and 30 kg/m(2) had IAAT by computed tomography, total fat and leg fat by dual-energy X-ray absorptiometry, aerobic fitness by a graded exercise test, African admixture (AFADM) by ancestry informative markers, blood lipids by the Ektachem DT system, and S(i) by glucose tolerance test. Independent of age, aerobic fitness, AFADM, and leg fat, IAAT was positively related to low-density lipoprotein-cholesterol (LDL-C), cholesterol-high-density lipoprotein (HDL) ratio, triglycerides (TGs), and fasting insulin (standardized beta varying 0.16-0.34) and negatively related to HDL-cholesterol (HDL-C) and S(i) (standardized beta -0.15 and -0.25, respectively). In contrast, independent of age, aerobic fitness, AFADM, and IAAT, leg fat was negatively related to total cholesterol, LDL-C, cholesterol-HDL ratio, TGs, and fasting insulin (standardized beta varying -0.15 to -0.21) and positively related to HDL-C and S(i) (standardized beta 0.16 and 0.23). Age was not independently related to worsening of any blood lipid but was related to increased S(i) (standardized beta for S(i) 0.25, insulin -0.31). With the exception of total cholesterol and LDL-C, aerobic fitness was independently related to worsened blood lipid profile and increased S(i) (standardized beta varying 0.17 to -0.21). Maintenance of favorable fat distribution and aerobic fitness may be important strategies for healthy aging, at least in premenopausal EA and AA women.
本研究旨在确定腹部内脏脂肪组织（IAAT）、腿部脂肪和有氧健身与欧洲裔美国女性（EA）和非裔美国女性（AA）的血脂和胰岛素敏感性（S（i））的独立关系。93 名 EA 和 94 名 AA 的 BMI 在 27 到 30 公斤/平方米之间，通过计算机断层扫描（CT）测量 IAAT，通过双能 X 射线吸收仪（DXA）测量总脂肪和腿部脂肪，通过分级运动试验测量有氧健身，通过祖先信息标记物（AFADM）测量非洲混合度，通过 Ektachem DT 系统测量血脂，通过葡萄糖耐量试验测量 S（i）。独立于年龄、有氧健身、AFADM 和腿部脂肪，IAAT 与低密度脂蛋白胆固醇（LDL-C）、胆固醇高密度脂蛋白（HDL）比值、甘油三酯（TGs）和空腹胰岛素呈正相关（标准化β值为 0.16-0.34），与 HDL-胆固醇（HDL-C）和 S（i）呈负相关（标准化β值分别为-0.15 和-0.25）。相比之下，独立于年龄、有氧健身、AFADM 和 IAAT，腿部脂肪与总胆固醇、LDL-C、胆固醇-HDL 比值、TGs 和空腹胰岛素呈负相关（标准化β值为-0.15 到-0.21），与 HDL-C 和 S（i）呈正相关（标准化β值分别为 0.16 和 0.23）。年龄与任何血脂恶化均无独立关系，但与 S（i）增加有关（S（i）标准化β值为 0.25，胰岛素为-0.31）。除了总胆固醇和 LDL-C 之外，有氧健身与血脂谱恶化和 S（i）增加独立相关（标准化β值为 0.17 到-0.21）。维持有利的脂肪分布和有氧健身可能是健康衰老的重要策略，至少在绝经前的 EA 和 AA 女性中是这样。
