身体活动不足和肥胖：与胰岛素抵抗和 2 型糖尿病的关系。

Physical inactivity and obesity: links with insulin resistance and type 2 diabetes mellitus.

机构信息

Exercise Metabolism Research Group, Human Performance Laboratory, School of Sport and Exercise Sciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

出版信息

Diabetes Metab Res Rev. 2009 Sep;25 Suppl 1:S18-23. doi: 10.1002/dmrr.983.

DOI:10.1002/dmrr.983

PMID:19662619

Abstract

Data from the health survey for England 2006, showed that the prevalence of type 2 diabetes mellitus (T2DM) has more than doubled in men and women since 1991. In the USA certain States have a prevalence of T2DM of greater than 10%. Globally it has been reported that this increase is by no means slowing down and that the number of individuals with the disease is expected to rise from 171 million cases reported in 2000 to 366 million by the year 2030. Physical inactivity and obesity are two major risk factors for the development of T2DM. In this review we will discuss evidence of an association between physical inactivity, obesity and T2DM from prospective cohort studies and clinical trials. We will also discuss some of the potential mechanisms that are thought to link obesity and physical inactivity with the major pathophysiological precursor of T2DM, insulin resistance.

摘要

来自 2006 年英格兰健康调查的数据显示，自 1991 年以来，男性和女性 2 型糖尿病（T2DM）的患病率增加了一倍多。在美国，某些州的 T2DM 患病率大于 10%。据全球报道，这种增长速度并没有放缓，预计到 2030 年，患病人数将从 2000 年报告的 1.71 亿例增加到 3.66 亿例。身体活动不足和肥胖是 T2DM 发展的两个主要危险因素。在本次综述中，我们将讨论前瞻性队列研究和临床试验中身体活动不足、肥胖与 T2DM 之间关联的证据。我们还将讨论一些被认为与肥胖和身体活动不足与 T2DM 的主要病理生理前体胰岛素抵抗相关的潜在机制。