Fujimori S, Shudo K, Hashimoto Y
Faculty of Pharmaceutical Science, University of Tokyo, Japan.
Nucleic Acids Symp Ser. 1990(22):97-8.
As a sugar-modified oligonucleotide, a hexamer of 9-(2-deoxy-beta-L-erythro-pentafuranosyl)-9H-purin-6-amine, [L-(dAp)5dA], was synthesized by triester method. The L-hexamer was resistant to bovine spleen phosphodiesterase. UV absorption studies indicated that L-hexamer formed a complex with poly U but not with poly dT at 0 degrees C. It was assumed that enantio-DNA's possese the ability to distinguish complementary RNA from DNA.
作为一种糖修饰的寡核苷酸，9-(2-脱氧-β-L-赤藓糖基)-9H-嘌呤-6-胺的六聚体[L-(dAp)5dA]通过三酯法合成。该L-六聚体对牛脾磷酸二酯酶具有抗性。紫外吸收研究表明，L-六聚体在0℃时与聚U形成复合物，但不与聚dT形成复合物。据推测，对映体DNA具有区分互补RNA和DNA的能力。
