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糖修饰的寡核苷酸。III（1）。α-和β-L-八聚胸苷酸的合成、核酸酶抗性及碱基配对性质

Sugar modified oligonucleotides. III (1). Synthesis, nuclease resistance and base pairing properties of alpha- and beta-L-octathymidylates.

作者信息

Morvan F, Génu C, Rayner B, Gosselin G, Imbach J L

机构信息

Université de Montpellier II, Laboratoire de Chimie Bio-Organique, URA 488, France.

出版信息

Biochem Biophys Res Commun. 1990 Oct 30;172(2):537-43. doi: 10.1016/0006-291x(90)90706-s.

DOI:10.1016/0006-291x(90)90706-s
PMID:2173569
Abstract

Two unnatural L-oligodeoxyribonucleotides, namely alpha- and beta-L-dT8pO(CH2)3OH, have been synthesized. These oligomers are resistant towards nuclease degradation. They do not show any UV detectable base pairing with beta-D-dA8 and poly rA.

摘要

已经合成了两种非天然的L - 寡脱氧核糖核苷酸，即α - 和β - L - dT8pO(CH2)3OH。这些寡聚物对核酸酶降解具有抗性。它们与β - D - dA8和聚rA没有显示出任何可通过紫外线检测到的碱基配对。

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